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Article

Striatal-Inoculation of α-Synuclein Preformed Fibrils Aggravated the Phenotypes of REM Sleep without Atonia in A53T BAC-SNCA Transgenic Mice.

International journal of molecular sciences - 2 Nov 2022

Okuda Shinya, Nakayama Takeo, Uemura Norihito, Hikawa Rie, Ikuno Masashi, Yamakado Hodaka, Inoue Haruhisa, Tachibana Naoko, Hayashi Yu, Takahashi Ryosuke, Egawa Naohiro

Abstract excerpt

Accumulation of α-synuclein (α-syn) is the pathological hallmark of α-synucleinopathy. Rapid eye movement (REM) sleep behavior disorder (RBD) is a pivotal manifestation of α-synucleinopathy including Parkinson's disease (PD). RBD is clinically confirmed by REM sleep without atonia (RWA) in polysomnography. To accurately characterize RWA preceding RBD and their underlying α-syn pathology, we inoculated α-syn...

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PMID: 36362177
DOI: 10.3390/ijms232113390
PMCID: PMC9656146

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