Article

Long-term exposure to PFE-360 in the AAV-α-synuclein rat model: findings and implications

2018-11-12

Abstract excerpt

<h4>Significance statement</h4> Treatment of Parkinson’s disease is reliant on symptomatic treatments, without any option to slow or halt disease progression. Mutations in LRRK2 and α-synuclein are known risk factors for Parkinson’s disease. Presence of α-synuclein aggregates at autopsies in both idiopathic and most G2019S cases is suggestive of a common disease pathogenesis. LRRK2 and α-synuclein interaction is...

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Literature Corpus work: 98969d22-5bb4-5380-9a0c-5e1f95f98154
DOI: 10.1101/465567

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