Article

Development and characterization of a non-human primate model of disseminated synucleinopathy

2023-12-15

Abstract excerpt

The presence of a widespread cortical synucleinopathy is the main neuropathological hallmark underlying clinical entities such as Parkinson’s disease with dementia (PDD) and dementia with Lewy bodies (DLB). There currently is a pressing need for the development of non-human primate (NHPs) models of PDD and DLB to further overcome existing limitations in drug discovery. Here we took advantage of a retrogradely-spre...

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Literature Corpus work: 377cb860-f88d-5788-b1e0-e40b8b76dc02
DOI: 10.1101/2023.12.15.571818

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