Article

PI 3-kinase isoform p110α controls smooth muscle cell functionality and protects against aortic aneurysm formation

2022-12-01

Abstract excerpt

<h4>Background</h4> Catalytic class IA PI 3-kinase isoform p110α is a crucial regulator of cellular proliferation and survival in numerous cell types. While p110α is critically involved in pathogenic vascular remodeling, its physiological role for vascular integrity under stress conditions has not been studied. We report a protective function of smooth muscle p110α against abdominal aortic aneurysm (AAA) formatio...

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Literature Corpus work: 4410e1a4-c883-5ab2-a38c-0d9774bf871b
DOI: 10.1101/2022.12.01.518561

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