MLL1 Regulates T-Cell Phenotype via Notch Signaling During Abdominal Aortic Aneurysm Development.

doi:10.1161/ATVBAHA.126.324552

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Article

MLL1 Regulates T-Cell Phenotype via Notch Signaling During Abdominal Aortic Aneurysm Development.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2026

He Xiaobing, Juriga Nicholas, Callow Brennan, Salih Sama, Joshi Amrita, Bogle Rachael, Tsoi Lam C, Obi Andrea T, Gudjonsson Johann E, Gallagher Katherine A, Davis Frank M

Abstract excerpt

BACKGROUND: Abdominal aortic aneurysms (AAA) are characterized by progressive pathological vascular remodeling and a dysregulated immune microenvironment marked by an imbalance between anti-inflammatory regulatory T cells and proinflammatory T helper 17 (Th17) cells within the aortic wall. The molecular mechanisms governing CD4+ (cluster of differentiation) T-cell differentiation during AAA development remain...

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Topics

Animals
Histone-Lysine N-Methyltransferase
Humans
Aortic Aneurysm, Abdominal
Signal Transduction

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Myeloid-Lymphoid Leukemia Protein

Phenotype

Mice, Inbred C57BL

Disease Models, Animal

Male

Th17 Cells

Receptor, Notch1

Mice

Aorta, Abdominal

Source

Open in PubMed Open full text

Identifiers

PMID: 42619610
DOI: 10.1161/ATVBAHA.126.324552
PMCID: PMC13496003

Genes

CD4
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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