Article
Pathophysiology of abdominal aortic aneurysms: insights from the elastase-induced model in mice with different genetic backgrounds.
Annals of the New York Academy of Sciences - 1 Nov 2006
Thompson Robert W, Curci John A, Ennis Terri L, Mao Dongli, Pagano Monica B, Pham Christine T N
Abstract excerpt
Abdominal aortic aneurysms (AAAs) represent a complex degenerative disorder involving chronic aortic wall inflammation and destructive remodeling of structural connective tissue. Studies using human AAA tissues have helped identify a variety of molecular mediators and matrix-degrading proteinases, which contribute to aneurysm disease, thereby providing a sound foundation for understanding AAAs; however, these...
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