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Pathogenesis of Abdominal Aortic Aneurysms: MicroRNAs, Proteases, Genetic Associations

26 Nov 2013

Abstract excerpt

Abdominal aortic aneurysm (AAA) disease is a common, morbid, and highly lethal pathology. Extraordinary efforts have been launched to determine the molecular and pathophysiological characteristics of AAAs. Although surgery is highly effective in preventing death by rupture for larger AAAs, no guidance or preventive therapy is currently available for the >90% of patients whose aneurysms are below the surgical...

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PMID: 24274177
DOI: 10.1146/annurev-med-101712-174206

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