Article
Genetic Ablation of miR-146a Induces Abdominal Aortic Aneurysm Formation by Intensifying Inflammatory M1-Like Macrophages Polarization and Vascular Smooth Muscle Cell Phenotypic Switching.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2025
Zhong Lintao, Sun Yili, Chen Guojun, Wang Junfen, Yang Zhiwen, Lu Weilin, Xiao Xiaoyong, Song Haoyu, Xiong Jie, Lin Beiyou, Wang Kun, Yang Shuai, Bin Jianping, Jiang Xiaofei
Abstract excerpt
BACKGROUND: Abdominal aortic aneurysm (AAA), a pathological dilation of the abdominal aorta, is primarily driven by chronic aortic wall inflammation. The well-established anti-inflammatory microRNA 146a (miR-146a) has been implicated as a key regulator in various chronic inflammatory pathologies. However, its potential functional role in the pathogenesis of AAA remains to be elucidated. METHODS: We constructed...
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