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Article

Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms.

Journal of vascular surgery - 1 Feb 2018

Xuan Haojun, Xu Baohui, Wang Wei, Tanaka Hiroki, Fujimura Naoki, Miyata Masaaki, Michie Sara A, Dalman Ronald L

Abstract excerpt

OBJECTIVE: Angiotensin (Ang) II type 1 receptor (AT1) activation is essential for the development of exogenous Ang II-induced abdominal aortic aneurysms (AAAs) in hyperlipidemic animals. Experimental data derived from this modeling system, however, provide limited insight into the role of endogenous Ang II in aneurysm pathogenesis. Consequently, the potential translational value of AT1 inhibition in clinical AAA...

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Share to Angiotensin II Type 1 Receptor Blockers
Share to Aorta, Abdominal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aortic Aneurysm, Abdominal

Share to Benzimidazoles

Share to Benzoates

Share to Dilatation, Pathologic

Share to Pancreatic Elastase

Share to Receptor, Angiotensin, Type 1

Source

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Identifiers

PMID: 28434702
DOI: 10.1016/j.jvs.2016.12.110
PMCID: PMC5650567

Genes

CCL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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