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Article

Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson’s disease and pharmacodynamic biomarkers

2022-06-06

Abstract excerpt

<title>Abstract</title> <p>Levels of expression or of phosphorylation of leucine-rich repeat kinase 2 (LRRK2) and its Rab substrates have the potential for use as disease or pharmacodynamic biomarkers. LRRK2 phosphorylation levels at the S910-S935-S955-S973 phosphosites are reduced for most disease mutant forms of LRRK2, while for phospho-S1292, phospho-T72-Rab8 and phospho-T73-Rab10 levels are increased for most...

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Literature Corpus work
85ed143d-233c-5e54-8491-0991e9104b69
DOI
10.21203/rs.3.rs-1677803/v1
Open publication

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