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Quantitative proteomics and phosphoproteomics of urinary extracellular vesicles define putative diagnostic biosignatures for Parkinson’s disease

10 May 2023

Abstract excerpt

BACKGROUND: Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been recognized as genetic risk factors for Parkinson's disease (PD). However, compared to cancer, fewer genetic mutations contribute to the cause of PD, propelling the search for protein biomarkers for early detection of the disease. METHODS: Utilizing 138 urine samples from four groups, healthy individuals (control), healthy individuals...

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PMID: 37165152
DOI: 10.1038/s43856-023-00294-w

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