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Article

Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers.

Acta neuropathologica communications - 22 Nov 2017

Wang Shijie, Liu Zhiyong, Ye Tao, Mabrouk Omar S, Maltbie Tyler, Aasly Jan, West Andrew B

Abstract excerpt

Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene can cause late-onset Parkinson disease (PD). LRRK2 mutations increase LRRK2 kinase activities that may increase levels of LRRK2 autophosphorylation at serine 1292 (pS1292) and neurotoxicity in model systems. pS1292-LRRK2 protein can be packaged into exosomes and measured in biobanked urine. Herein we provide evidence that pS1292-LRRK2 protein is...

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Identifiers

PMID: 29166931
DOI: 10.1186/s40478-017-0492-y
PMCID: PMC5700679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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