Article

Multi-cohort, cross-species urinary proteomics reveals signatures of LRRK2 dysfunction in Parkinson’s disease

2025-11-07

Abstract excerpt

Pathogenic mutations in Leucine-rich repeat kinase 2 ( LRRK2 ) are the predominant genetic cause of Parkinson’s disease (PD) and often increase kinase activity, making LRRK2 inhibitors promising treatment options. Although LRRK2 kinase inhibitors are advancing clinically, non-invasive readouts of LRRK2-linked pathway modulation remain limited. Profiling urinary proteomes from 1,215 individuals across three cohort...

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Literature Corpus work: 1b27a79f-518a-58f8-ad86-9f5b2257cb1c
DOI: 10.1101/2025.11.06.686787

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