Article

Human cortico-vascular assembloids reveal a CELF2-AHNAK-dependent switch from neuronal to endothelial tropism in glioblastoma cells

2025-10-22

Abstract excerpt

<h4>ABSTRACT</h4> Glioblastoma (GB) remains one of the most aggressive human cancers, driven by profound cellular plasticity and dynamic interactions with the neurovascular niche. Yet, existing preclinical models fail to reproduce the human brain-vascular interface, limiting studies of tumor-host crosstalk and invasion. To overcome this gap, we developed a human induced pluripotent stem cell (hiPSC)-derived corti...

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Literature Corpus work: 85e9eedc-0832-51f7-9f14-6b22ec599c90
DOI: 10.1101/2025.10.21.683634

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