Article

Transcriptomic Rewiring of Glioblastoma Organoids Reveals an NPC2-associated Neuronal Mimicry Program

2026-08-11

Abstract excerpt

<title>Abstract</title> <p> Patient-derived organoids (PDOs) model glioblastoma (GBM), but how isolation from the native microenvironment reshapes malignant cell states remains poorly understood. After re-analyzing public single-cell RNA sequencing datasets of paired primary GBM tissue and derived organoids, we found that <italic>in vitro</italic> microenvironmental deprivation drives a convergent mesenchymal...

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Literature Corpus work: 5913e9ea-0fdd-5853-9256-a0d1a53f0e4e
DOI: 10.21203/rs.3.rs-10605560/v1

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