Article

Understanding proneural–mesenchymal transition using patient-derived glioma stem-like cell (GSC) organoids and engineered extracellular matrix

2025-09-20

Abstract excerpt

Glioblastoma multiforme (GBM) is a highly aggressive, angiogenic WHO grade IV glioma marked by rapid progression, therapeutic resistance, and poor prognosis. A defining feature of GBM is the presence of glioma stem-like cells (GSCs), which reside in specialized perivascular niches and drive tumor progression, recurrence, and therapeutic resistance. The blood-brain barrier, coupled with the complex and dynamic tumo...

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Literature Corpus work: fc1eb084-f956-5b92-a01b-bb458f40fc46
DOI: 10.1101/2025.09.17.676829

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