Article

Spatiotemporal analysis of glioma heterogeneity reveals Col1A1 as an actionable target to disrupt tumor mesenchymal differentiation, invasion and malignancy

2020-12-02

Abstract excerpt

<h4>ABSTRACT</h4> Intra-tumoral heterogeneity and diffuse infiltration are hallmarks of glioblastoma that challenge treatment efficacy. However, the mechanisms that set up both tumor heterogeneity and invasion remain poorly understood. Herein, we present a comprehensive spatiotemporal study that aligns distinctive intra-tumoral histopathological structures, oncostreams, with dynamic properties and a unique, actio...

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Literature Corpus work: a7668ba6-dfdd-55fa-b163-b865259d72c2
DOI: 10.1101/2020.12.01.404970

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