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Article

PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease.

PLoS genetics - 1 Apr 2021

Nackenoff Alex G, Hohman Timothy J, Neuner Sarah M, Akers Carolyn S, Weitzel Nicole C, Shostak Alena, Ferguson Shawn M, Mobley Bret, Bennett David A, Schneider Julie A, Jefferson Angela L, Kaczorowski Catherine C, Schrag Matthew S

Abstract excerpt

Phospholipase D3 (PLD3) is a protein of unclear function that structurally resembles other members of the phospholipase D superfamily. A coding variant in this gene confers increased risk for the development of Alzheimer's disease (AD), although the magnitude of this effect has been controversial. Because of the potential significance of this obscure protein, we undertook a study to observe its distribution in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33830999
DOI: 10.1371/journal.pgen.1009406
PMCID: PMC8031396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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