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Article

PLD3 in Alzheimer's Disease: a Modest Effect as Revealed by Updated Association and Expression Analyses.

Molecular neurobiology - 1 Aug 2016

Zhang Deng-Feng, Fan Yu, Wang Dong, Bi Rui, Zhang Chen, Fang Yiru, Yao Yong-Gang

Abstract excerpt

Alzheimer's disease (AD) is the most common form of dementia. Numerous genome-wide association studies (GWASs) have found several AD susceptibility common loci but with limited effect size. Recent next-generation sequencing studies of large AD pedigrees had identified phospholipase D3 (PLD3) p.V232M as the potentially functional rare variant with causal effect. However, four follow-up replication studies (Brief...

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Source

Identifiers

PMID: 26189833
DOI: 10.1007/s12035-015-9353-5

Genes

PLD3
PLD2
PLD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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