PLD3 epigenetic changes in the hippocampus of Alzheimer's disease.

doi:10.1186/s13148-018-0547-3

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

PLD3 epigenetic changes in the hippocampus of Alzheimer's disease.

Clinical epigenetics - 12 Sept 2018

Blanco-Luquin Idoia, Altuna Miren, Sánchez-Ruiz de Gordoa Javier, Urdánoz-Casado Amaya, Roldán Miren, Cámara María, Zelaya Victoria, Erro María Elena, Echavarri Carmen, Mendioroz Maite

Abstract excerpt

BACKGROUND: Whole-exome sequencing has revealed a rare missense variant in PLD3 gene (rs145999145) to be associated with late onset Alzheimer's disease (AD). Nevertheless, the association remains controversial and little is known about the role of PLD3 in AD. Interestingly, PLD3 encodes a phospholipase that may be involved in amyloid precursor protein (APP) processing. Our aim was to gain insight into the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Peptides

Share to CpG Islands

Share to DNA Methylation

Share to Down-Regulation

Share to Epigenesis, Genetic

Share to Hippocampus

Share to Phospholipase D

Source

Open in PubMed Open full text

Identifiers

PMID: 30208929
DOI: 10.1186/s13148-018-0547-3
PMCID: PMC6134774

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PLD3 epigenetic changes in the hippocampus of Alzheimer's disease.PMID 30208929Read ↗

PLD3 in Alzheimer's disease.Semantic proximity Read ↗

PLD3 in Alzheimer's Disease: a Modest Effect as Revealed by Updated Association and Expression Analyses.Semantic proximity Read ↗

Phospholipase D3 contributes to Alzheimer’s disease risk via disruption of Aβ clearance and microglia response to amyloid plaquesSemantic proximity Read ↗

PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer’s diseaseSemantic proximity Read ↗

PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease.Semantic proximity Read ↗

PLD3 Rare Variants Identified in Late-Onset Alzheimer’s Disease Affect Amyloid-β Levels in Cellular ModelSemantic proximity Read ↗

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease.Semantic proximity Read ↗

Early epigenetic changes of Alzheimer’s disease in the human hippocampusSemantic proximity Read ↗

Common Variant in PLD3 Influencing Cerebrospinal Fluid Total Tau Levels and Hippocampal Volumes in Mild Cognitive Impairment Patients from the ADNI Cohort.Semantic proximity Read ↗

DNA methylation signature of human hippocampus in Alzheimer’s disease is linked to neurogenesisSemantic proximity Read ↗

Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s diseaseSemantic proximity Read ↗

Methylation differences in Alzheimer’s disease neuropathologic change in the aged human brainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.