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Phospholipase D3 regulates lysosomal morphology, biogenesis, and function in neurons

2024-09-26

Abstract excerpt

Phospholipase D3 (PLD3) is a lysosomal protein in neurons and is linked to an Alzheimer’s disease (AD) risk through coding variants. Its role in lysosomal abnormalities observed in AD remains unclear. We conducted a comprehensive study integrating transcriptomic, proteomic, and cell biology approaches to investigate PLD3’s role in lysosome function in neurons. PLD3 undergoes aberrant ubiquitination in AD brain tis...

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Identifiers and source

Literature Corpus work
551927a3-81d4-5018-9e2d-0dfafcf35a67
DOI
10.1101/2024.09.26.615214
Open publication

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Phospholipase D3 regulates lysosomal morphology, biogenesis, and function in neuronsDOI 10.1101/2024.09.26.615214
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