Article
Common Variants in PLD3 and Correlation to Amyloid-Related Phenotypes in Alzheimer's Disease.
Journal of Alzheimer's disease : JAD - 1 Jan 2015
Wang Chong, Tan Lan, Wang Hui-Fu, Yu Wan-Jiang, Liu Ying, Jiang Teng, Tan Meng-Shan, Hao Xiao-Ke, Zhang Dao-Qiang, Yu Jin-Tai
Abstract excerpt
The phospholipase D3 (PLD3) gene has shown association with Alzheimer's disease (AD). However, the role of PLD3 common variants in amyloid-β (Aβ) pathology remains unclear. We examined the association of thirteen common single nucleotide polymorphisms (SNPs) with cerebrospinal fluid (CSF) Aβ(1- 42) levels and florbetapir retention on florbetapir 18F amyloid positron emission tomography (AV45-PET) in a large...
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