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Simultaneous polyclonal antibody sequencing and epitope mapping by cryo electron microscopy and mass spectrometry – a perspective

2024-06-22

Abstract excerpt

Antibodies are a major component of adaptive immunity against invading pathogens. Here we explore possibilities for an analytical approach to characterize the antigen-specific antibody repertoire directly from the secreted proteins in convalescent serum. This approach aims to perform simultaneous antibody sequencing and epitope mapping using a combination of single particle cryo-electron microscopy (cryoEM) and bo...

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Identifiers and source

Literature Corpus work
85a1a151-d673-5982-ac3d-89034f1b43e0
DOI
10.1101/2024.06.21.600107
Open publication

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Simultaneous polyclonal antibody sequencing and epitope mapping by cryo electron microscopy and mass spectrometry – a perspectiveDOI 10.1101/2024.06.21.600107
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