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Epitope profiling using computational structural modelling demonstrated on coronavirus-binding antibodies

13 Dec 2021

Abstract excerpt

Identifying the epitope of an antibody is a key step in understanding its function and its potential as a therapeutic. Sequence-based clonal clustering can identify antibodies with similar epitope complementarity, however, antibodies from markedly different lineages but with similar structures can engage the same epitope. We describe a novel computational method for epitope profiling based on structural modelling...

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Share to Monoclonal and Polyclonal Antibodies Research
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PMID: 34898603
DOI: 10.1371/journal.pcbi.1009675

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