Article

Functional and epitope specific monoclonal antibody discovery directly from immune sera using cryoEM

2024-12-09

Abstract excerpt

Antibodies are crucial therapeutics, comprising a significant portion of approved drugs due to their safety and clinical efficacy. Traditional antibody discovery methods are labor-intensive, limiting scalability and high-throughput analysis. Here, we improved upon our streamlined approach combining structural analysis and bioinformatics to infer heavy and light chain sequences from electron potential maps of serum...

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Identifiers and source

Literature Corpus work: 68eb62ca-52b2-5c48-acec-377c1a929bb2
DOI: 10.1101/2024.12.06.627063

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