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Template-Based Assembly of Proteomic Short Reads For De Novo Antibody Sequencing and Repertoire Profiling

14 Jul 2022

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide Antibodies can target a vast molecular diversity of antigens. This is achieved by generating a complementary diversity of antibody sequences through somatic recombination and hypermutation. A full understanding of the antibody repertoire in health and disease therefore requires dedicated de novo sequencing methods. Next-generation cDNA sequencing methods have...

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PMID: 35834437
DOI: 10.1021/acs.analchem.2c01300

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