AbNovoBench: a resource and benchmarking platform for monoclonal antibody de novo sequencing

Abstract excerpt

Monoclonal antibodies (mAbs) are critical in disease diagnostics and therapeutics, yet the performance of mass spectrometry (MS)-based de novo sequencing remains incompletely characterized due to limited antibody-specific datasets and the absence of a standardized benchmark framework. Here we present AbNovoBench, a comprehensive framework for evaluating data analysis strategies for mAb de novo sequencing. It featu...

Topics

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• Antibodies, Neutralizing
• Biosimilars and Bioanalytical Methods
• CAR-T cell therapy research
• Glycosylation and Glycoproteins Research
• HIV Research and Treatment
• Monoclonal and Polyclonal Antibodies Research
• Multiple Myeloma Research and Treatments
• Protein purification and stability

Identifiers and source

Literature Corpus work

25ec68c5-b64a-54c3-9d77-544863c6812c

DOI

10.64898/2026.02.02.703105