Article

CryoEM Structures of Antibodies Elicited by Germline-Targeting HIV MPER Epitope-Scaffolds

2025-08-19

Abstract excerpt

Applying cryoEM to small protein complexes is usually challenging due to their lack of features for particle alignment. Here, we characterized antibody responses to 21 kDa HIV membrane-proximal external region germline-targeting (MPER-GT) immunogens through cryoEM by complexing them with 10E8 or Fabs derived from MPER-GT immunized animals. Distinct antibody-antigen interactions were analyzed using atomic models ge...

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Literature Corpus work: e07c73fa-fc1f-5f0a-adfd-c18162810b08
DOI: 10.1101/2025.08.19.671101

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