Template-based assembly of proteomic short reads for <i>de novo</i> antibody sequencing and repertoire profiling

Abstract excerpt

Antibodies can target a vast molecular diversity of antigens. This is achieved by generating a complementary diversity of antibody sequences though somatic recombination and hypermutation. A full understanding of the antibody repertoire in health and disease therefore requires dedicated de novo sequencing methods. Next generation cDNA sequencing methods have laid the foundation of our current understanding of the...

Topics

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• CAR-T cell therapy research
• Glycosylation and Glycoproteins Research
• Immune Cell Function and Interaction
• Immunotherapy and Immune Responses
• Monoclonal and Polyclonal Antibodies Research
• Multiple Myeloma Research and Treatments
• T-cell and B-cell Immunology
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

4e70b349-3d6a-53f1-837f-eead246b3944

DOI

10.1101/2022.03.07.483237