Article

Cdc42 is required for cytoskeletal support of endothelial cell adhesion during blood vessel formation in mice

2015-09-15

Abstract excerpt

The Rho family of small GTPases has been shown to be required in endothelial cells (ECs) during blood vessel formation. However, the underlying cellular events controlled by different GTPases remain unclear. Here, we assess the cellular mechanisms by which Cdc42 regulates mammalian vascular morphogenesis and maintenance. In vivo deletion of Cdc42 in embryonic ECs (Cdc42(Tie2KO)) results in blocked lumen formation...

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Literature Corpus work: 857c42bc-3a5b-5e8d-8d2b-0df35fc6c6a7
DOI: 10.1242/jcs.179606

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