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Article

Inactivation of Cdc42 in neural crest cells causes craniofacial and cardiovascular morphogenesis defects.

Developmental biology - 15 Nov 2013

Liu Yang, Jin Yixin, Li Jieli, Seto Edward, Kuo Enoch, Yu Wei, Schwartz Robert J, Blazo Maria, Zhang Shenyuan L, Peng Xu

Abstract excerpt

Neural crest cells (NCCs) are physically responsible for craniofacial skeleton formation, pharyngeal arch artery remodeling and cardiac outflow tract septation during vertebrate development. Cdc42 (cell division cycle 42) is a Rho family small GTP-binding protein that works as a molecular switch to regulate cytoskeleton remodeling and the establishment of cell polarity. To investigate the role of Cdc42 in NCCs...

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Source

Identifiers

PMID: 24056078
DOI: 10.1016/j.ydbio.2013.09.013

Genes

BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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