Article

Cdc42 is required for lymphatic branching, maturation and valve formation during embryonic development

2020-01-29

Abstract excerpt

Cdc42, a Ras-related GTPase that regulates the actin cytoskeleton, was recently shown to play an indispensable role in vasculogenesis and endothelial cell (EC) survival. Here, we determined whether Cdc42 also contributes to lymphatic development by generated two different Cdc42 knockout mice lines by crossing Cdc42/flox mice with either vascular endothelial cadherin-Cre (Cdh5α-Cre) mice or Prox1-CreER T2 mice. Ou...

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Identifiers and source

Literature Corpus work: 980ab333-8d04-5eef-b7ae-df9a93c6e28f
DOI: 10.1101/2020.01.28.923847

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