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Article

The guanine nucleotide exchange factor C3G is necessary for the formation of focal adhesions and vascular maturation.

Development (Cambridge, England) - 1 Jan 2003

Voss Anne K, Gruss Peter, Thomas Tim

Abstract excerpt

The Ras signalling pathway has major roles in normal cell function and oncogenesis. C3G is a guanine nucleotide exchange factor for members of the Ras family of GTPases. We generated a mouse strain with a hypomorphic C3G allele. C3G(gt/gt) mutant embryos died of vascular defects around E11.5 due...

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Identifiers

PMID: 12466202
DOI: 10.1242/dev.00217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12466202-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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