Article

The mec-2e isoform with a large C-terminal completely rescues the touch sensation defect of C. elegans

2024-10-21

Abstract excerpt

<title>Abstract</title> <p>Human podocin and <italic>C. elegans</italic> MEC-2 belong to the stomatin protein superfamily. They share 49% identity and 91% similarity both in the evolutionary conserved PHB domain (123-284aa) and in the oligomerization region (273-351aa). Amino acid substitutions in these conserved regions can modify the podocin oligomerization and thus the pathogenicity of trans-associated <italic...

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Literature Corpus work: 855e89d0-ca55-5555-b810-07685c3640f3
DOI: 10.21203/rs.3.rs-5187042/v1

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