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Article

MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation.

Nature - 28 Feb 2002

Goodman Miriam B, Ernstrom Glen G, Chelur Dattananda S, O'Hagan Robert, Yao C Andrea, Chalfie Martin

Abstract excerpt

Touch sensitivity in animals relies on nerve endings in the skin that convert mechanical force into electrical signals. In the nematode Caenorhabditis elegans, gentle touch to the body wall is sensed by six mechanosensory neurons that express two amiloride-sensitive Na+ channel proteins (DEG/ENaC). These proteins, MEC-4 and MEC-10, are required for touch sensation and can mutate to cause neuronal degeneration....

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PMID: 11875573
DOI: 10.1038/4151039a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation.PMID 11875573Read ↗

Spatial asymmetry in the mechanosensory phenotypes of the C. elegans DEG/ENaC gene mec-10.Semantic proximity Read ↗

The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals.Semantic proximity Read ↗

MEC-10 and MEC-19 Reduce the Neurotoxicity of the MEC-4(d) DEG/ENaC Channel in Caenorhabditis elegans.Semantic proximity Read ↗

MEC-2 is recruited to the putative mechanosensory complex in C. elegans touch receptor neurons through its stomatin-like domain.Semantic proximity Read ↗

A stomatin-like protein necessary for mechanosensation in C. elegans.Semantic proximity Read ↗

Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins.Semantic proximity Read ↗

Neurotoxic unc-8 mutants encode constitutively active DEG/ENaC channels that are blocked by divalent cations.Semantic proximity Read ↗

Temperature-sensitive mutant of the Caenorhabditis elegans neurotoxic MEC-4(d) DEG/ENaC channel identifies a site required for trafficking or surface maintenance.Semantic proximity Read ↗

Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade.Semantic proximity Read ↗

A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans.Semantic proximity Read ↗

A stomatin-domain protein essential for touch sensation in the mouse.Semantic proximity Read ↗

The mec-2e isoform with a large C-terminal completely rescues the touch sensation defect of C. elegansSemantic proximity Read ↗

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