Article
Loss of Bardet Biedl syndrome proteins causes defects in peripheral sensory innervation and function.
Proceedings of the National Academy of Sciences of the United States of America - 30 Oct 2007
Tan Perciliz L, Barr Travis, Inglis Peter N, Mitsuma Norimasa, Huang Susan M, Garcia-Gonzalez Miguel A, Bradley Brian A, Coforio Stephanie, Albrecht Phillip J, Watnick Terry, Germino Gregory G, Beales Philip L, Caterina Michael J, Leroux Michel R, Rice Frank L, Katsanis Nicholas
Abstract excerpt
Reception and interpretation of environmental stimuli is critical for the survival of all organisms. Here, we show that the ablation of BBS1 and BBS4, two genes mutated in Bardet-Biedl syndrome and that encode proteins that localize near the centrioles of sensory neurons, leads to alterations of s.c. sensory innervation and trafficking of the thermosensory channel TRPV1 and the mechanosensory channel STOML3, with...
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