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Article

Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins.

Molecular biology of the cell - 15 Apr 2016

Chen Yushu, Bharill Shashank, Altun Zeynep, O'Hagan Robert, Coblitz Brian, Isacoff Ehud Y, Chalfie Martin

Abstract excerpt

Caenorhabditis eleganssenses gentle touch via a mechanotransduction channel formed from the DEG/ENaC proteins MEC-4 and MEC-10. An additional protein, the paraoxonase-like protein MEC-6, is essential for transduction, and previous work suggested that MEC-6 was part of the transduction complex. We found that MEC-6 and a similar protein, POML-1, reside primarily in the endoplasmic reticulum and do not colocalize...

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Identifiers

PMID: 26941331
DOI: 10.1091/mbc.E15-08-0561
PMCID: PMC4831881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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