Article

Uncovering the essential roles of human GCP 2 orthologs in <i>Caenorhabditis elegans</i>

2023-02-27

Abstract excerpt

Human glutamate carboxypeptidase 2 (GCP2) from the M28B metalloprotease group is an important target for therapy in neurological disorders and an established tumor marker. However, its physiological functions remain unclear. To better understand general roles, we used the model organism Caenorhabditis elegans genetically manipulate its three existing orthologous genes and evaluate the impact on worm physiology. T...

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Literature Corpus work: 477504e3-b255-5676-89c7-a5712c8d84a5
DOI: 10.1101/2023.02.27.529682

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