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Synaptotagmin 13 is neuroprotective across motor neuron diseases

17 Feb 2020

Abstract excerpt

In amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), spinal and lower brainstem motor neurons degenerate, but some motor neuron subtypes are spared, including oculomotor neurons (OMNs). The mechanisms responsible for this selective degeneration are largely unknown, but the molecular signatures of resistant and vulnerable motor neurons are distinct and offer clues to neuronal resilience and...

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PMID: 32065260
DOI: 10.1007/s00401-020-02133-x

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