Article

Spatial transcriptomics identifies dysregulated programs across neural and non-neural tissues in spinal muscular atrophy

2026-03-23

Abstract excerpt

<h4>ABSTRACT</h4> Spinal muscular atrophy (SMA) is caused by insufficient levels of the survival motor neuron (SMN) protein and clinically manifests as profound weakness due to motor neuron degeneration. While recent evidence suggests it is a multisystem disorder, the pathological programs in neural and peripheral tissues are poorly understood. We applied spatial transcriptomics to cross-sections from the entire...

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Literature Corpus work: bbe61fa0-d6e1-5bba-81db-1bbf5a842b55
DOI: 10.64898/2026.03.20.713154

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