Article
Unravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to excitotoxicity.
Acta neuropathologica - 1 Jan 2013
Brockington Alice, Ning Ke, Heath Paul R, Wood Elizabeth, Kirby Janine, Fusi Nicolò, Lawrence Neil, Wharton Stephen B, Ince Paul G, Shaw Pamela J
Abstract excerpt
A consistent clinical feature of amyotrophic lateral sclerosis (ALS) is the sparing of eye movements and the function of external sphincters, with corresponding preservation of motor neurons in the brainstem oculomotor nuclei, and of Onuf's nucleus in the sacral spinal cord. Studying the differences in properties of neurons that are vulnerable and resistant to the disease process in ALS may provide insights into...
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