Article
Mutations in Noncoding Cis-Regulatory Elements Reveal Cancer Driver Cistromes in Luminal Breast Cancer.
Molecular cancer research : MCR - 1 Jan 2022
El Ghamrasni Samah, Quevedo Rene, Hawley James, Mazrooei Parisa, Hanna Youstina, Cirlan Iulia, Zhu Helen, Bruce Jeff P, Oldfield Leslie E, Yang S Y Cindy, Guilhamon Paul, Reimand Jüri, Cescon Dave W, Done Susan J, Lupien Mathieu, Pugh Trevor J
Abstract excerpt
Whole-genome sequencing of primary breast tumors enabled the identification of cancer driver genes and noncoding cancer driver plexuses from somatic mutations. However, differentiating driver from passenger events among noncoding genetic variants remains a challenge. Herein, we reveal cancer-driver cis-regulatory elements linked to transcription factors previously shown to be involved in development of luminal...
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