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Article

Widespread perturbation of ETS factor binding sites in cancer.

Nature communications - 17 Feb 2023

Carrasco Pro Sebastian, Hook Heather, Bray David, Berenzy Daniel, Moyer Devlin, Yin Meimei, Labadorf Adam Thomas, Tewhey Ryan, Siggers Trevor, Fuxman Bass Juan Ignacio

Abstract excerpt

Although >90% of somatic mutations reside in non-coding regions, few have been reported as cancer drivers. To predict driver non-coding variants (NCVs), we present a transcription factor (TF)-aware burden test based on a model of coherent TF function in promoters. We apply this test to NCVs from the Pan-Cancer Analysis of Whole Genomes cohort and predict 2555 driver NCVs in the promoters of 813 genes across 20...

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Identifiers

PMID: 36808133
DOI: 10.1038/s41467-023-36535-8
PMCID: PMC9938127

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