Article

A Robust Framework for Predicting Mutation Effects on Transcription Factor Binding: Insights from Mutational Signatures in 560 Breast Cancer Genomes

2026-03-13

Abstract excerpt

<title>Abstract</title> <p>Background: A vast majority of somatic mutations in cancer reside in noncoding regions, yet systematically predicting their functional impact on gene regulation remains a significant challenge. These variants often enforce their effects by altering the binding affinity of transcription factors (TFs) to cis-regulatory elements. However, a critical gap exists in linking specific mutationa...

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Literature Corpus work: 363e769f-7178-5309-aba9-e88e7816277f
DOI: 10.21203/rs.3.rs-8907367/v1

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