Cell-surface glycans are quantitative reporters of Golgi dysfunction in single cells

Abstract excerpt

Complex sugar polymers known as glycans contribute to the high molecular diversity of the eukaryotic cell surface. The types and levels of glycans on one cell can be sensed by other cells using carbohydrate-specific binding proteins such as lectins, enabling glycans to regulate cell-cell interactions. Glycans are covalently assembled onto proteins and lipids as they traverse the secretory pathway, a tightly regula...

Topics

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• Golgi Apparatus
• HeLa Cells
• High-Throughput Screening Assays
• Polysaccharides
• Reproducibility of Results
• RNA Interference
• RNA, Small Interfering
• Unsupervised Machine Learning

Identifiers and source

Literature Corpus work

84f53002-8134-5cff-a6d1-372e3926afd7

DOI

10.1101/2024.06.17.599374