Article
Giantin-knockout models reveal a feedback loop between Golgi function and glycosyltransferase expression.
Journal of cell science - 15 Dec 2017
Stevenson Nicola L, Bergen Dylan J M, Skinner Roderick E H, Kague Erika, Martin-Silverstone Elizabeth, Robson Brown Kate A, Hammond Chrissy L, Stephens David J
Abstract excerpt
The Golgi is the cellular hub for complex glycosylation, controlling accurate processing of complex proteoglycans, receptors, ligands and glycolipids. Its structure and organisation are dependent on golgins, which tether cisternal membranes and incoming transport vesicles. Here, we show that knockout of the largest golgin, giantin, leads to substantial changes in gene expression but only limited effects on Golgi...
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