Article

Giantin knockout models reveal a feedback loop between Golgi function and glycosyltransferase expression

2017-04-03

Abstract excerpt

The Golgi is the cellular hub for complex glycosylation, controlling accurate processing of complex proteoglycans, receptors, ligands, and glycolipids. Its structure and organisation is dependent on golgins, which tether cisternal membranes and incoming transport vesicles. Here we show that knockout of the largest golgin, giantin, leads to substantial changes in gene expression despite only limited effects on Golg...

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Literature Corpus work: 90329777-3219-5351-ab57-ae80770907e4
DOI: 10.1101/123547

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