Article
Glycan structures contain information for the spatial arrangement of glycoproteins in the plasma membrane.
PloS one - 1 Jan 2013
Hall M Kristen, Weidner Douglas A, Chen Jian ming, Bernetski Christopher J, Schwalbe Ruth A
Abstract excerpt
Glycoconjugates at the cell surface are crucial for cells to communicate with each other and the extracellular microenvironment. While it is generally accepted that glycans are vectorial biopolymers, their information content is unclear. This report provides evidence that distinct N-glycan structures influence the spatial arrangement of two integral membrane glycoproteins, Kv3.1 and E-cadherin, at the adherent...
Topics
- Animals
- CHO Cells
- Cadherins
- Cell Adhesion
- Cell Membrane
- Cell Movement
- Cricetinae
- Cricetulus
- Genetic Vectors
- Glycoproteins
- Glycosylation
- Green Fluorescent Proteins
- Lectins
- Microscopy, Fluorescence
- Mutation
- Polymers
- Polysaccharides
- Shaw Potassium Channels