RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells.

doi:10.1038/msb.2012.59

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Article

RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells.

Molecular systems biology - 1 Jan 2012

Chia Joanne, Goh Germaine, Racine Victor, Ng Susanne, Kumar Pankaj, Bard Frederic

Abstract excerpt

The Golgi apparatus has many important physiological functions, including sorting of secretory cargo and biosynthesis of complex glycans. These functions depend on the intricate and compartmentalized organization of the Golgi apparatus. To investigate the mechanisms that regulate Golgi architecture, we developed a quantitative morphological assay using three different Golgi compartment markers and quantitative...

Topics

Actomyosin
Cell Cycle
Computational Biology
Fluorescent Antibody Technique
Gene Expression Regulation
Glycosylation
Golgi Apparatus
HeLa Cells
Humans
Image Processing, Computer-Assisted
Lectins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microscopy, Fluorescence

Phenotype

Phosphoric Monoester Hydrolases

Pilot Projects

Polysaccharides

Protein Kinases

RNA Interference

Source

Open in PubMed Open full text

Identifiers

PMID: 23212246
DOI: 10.1038/msb.2012.59
PMCID: PMC3542528

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23212246-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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