Article

A triple fluorescence approach to measure O-GlcNAc dyshomeostasis in stem cells

2025-07-13

Abstract excerpt

O-GlcNAcylation is an essential post-translational modification, the complete loss of which results in lethality. Despite modifying thousands of nucleocytoplasmic proteins, O-GlcNAc is controlled by just two enzymes: O-GlcNAc transferase (OGT), which adds the modification, and O-GlcNAcase (OGA), which removes it. Disruptions in O-GlcNAc homeostasis, such as an imbalanced OGT/OGA ratio or aberrant O-GlcNAc levels,...

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Literature Corpus work: d8247079-85cd-5dce-aebd-0bc310a773da
DOI: 10.1101/2025.07.12.664510

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